“Give me a chance to create a fever and I will cure any disease.” (Parmenides, Greek physician and philosopher, 540-480 B.C.) Putting fever to use for therapeutic purposes has a long tradition. Modern medicine has proved the importance of pyretotherapy (fever therapy) in numerous studies.

During active hyperthermia pyrogenic substances are administered in order to increase the body temperature. Apyrexia and low susceptibility to infections are directly associated to an increased risk of malignant diseases. In 1891, Coley, MD., USA, reports about the spontaneous involution of tumors after long-term febrile episodes.

The impact of the pyretotherapy is subject to the temperature (38.5° – 40.5°) and the therapy duration (approximately 6 months). Fever activates messengers such as cytokines, TNF-Alpha, the cellular and humoral immune system and phagocytes (scavenger cells). This complex chain reaction causes a retuning of the organism.